Genetic polymorphisms detected in ORF of VKORC1 gene
Position in ORF | Substitution | Effect | Dose | Reference |
|---|---|---|---|---|
| 47G>C | C16S | No change | 2.7 mg/day | Obayashi et al., 2006 |
| 85G>T | V29L | Resistance | 100 mg/week | Rost et al., 2004 |
| 106G>T | D36Y | Resistance | 80 mg/week | Loebstein et al., 2006 |
| 112G>T | D38Y | No change | 5.3 mg/day | D'Andrea et al., 2005 |
| 121G>T | A41S | Resistance | 15.5 mg/day | Rieder et al., 2005 |
| 129C>T | C43C | N.A. | N.A. | Rost et al., 2004 |
| 129C>T | C43C | No effect | N.A. | D'Andrea et al., 2005 |
| 134T>C | V45A | Resistance | No response | Rost et al., 2004 |
| 172A>G | R58G | Resistance | 220 mg/week | Rost et al., 2004 |
| 196G>A | V66M | Resistance | 25 mg/day | Harrington et al., 2005 |
| 203A>G | H68R | No change | 3.8 mg/day | Obayashi et al., 2006 |
| 292C>T | R98W | Inactive VKOR | N.A. | Rost et al., 2004 |
| 358C>T | L120L | N.A. | N.A. | Rost et al., 2004 |
| 358C>T | L120L | No effect | N.A. | D'Andrea et al., 2005 |
| 383T>G | L128R | Resistance | No response | Rost et al., 2004 |
| 383T>G | L128R | Resistance | 45 mg/day | Bodin et al., 2005 |
| 452G>A | R151Q | No effect | 3.7 mg/day |
D'Andrea et al., 2005
|
N.A., not available.