TABLE 3

Pharmacokinetic parameters following a single oral dose of Sch527123

Species
Dose
Cmax
AUC (0-48 h)
BAa
mg/kg μM μM/h %
Mouse 25 17.0 31.5b 44
Rat 10 5.0 23.0 33
Monkey
3
0.9
4.0
39

  • ↵ a Bioavailability.

  • ↵ b AUC (0-24 h).