Pharmacokinetics of MDZ in hPXR mice pretreated with or without RIFax, at 10 mg/kg/day for 3 days Serum MDZ and 1′-OH-MDZ were detected by LC-MS/MS. AUC0–90 min for MDZ and 1′-OH-MDZ were estimated from the plasma concentration-time data by a noncompartmental approach using WinNonlin (Pharsight). Cmax and Tmax were obtained from the original data. Data are expressed as means ± S.D., n = 3.
Control | RIFax | RIFax/Control | |
|---|---|---|---|
| MDZ | |||
| Cmax (nM) | 477 ± 40.3 | 383 ± 19.1 | 0.8 |
| Tmax (min) | 10.0 ± 0.0 | 12.5 ± 10.6 | 1.3 |
| AUC0–90 min (μmol · min/l) | 8.0 ± 0.4 | 8.9 ± 0.7 | 1.1 |
| 1′-OH-MDZ | |||
| Cmax (nM) | 562 ± 4.9 | 823 ± 55.2* | 1.5 |
| Tmax (min) | 25.0 ± 7.1 | 7.5 ± 3.5* | 0.3 |
| AUC0–90 min (μmol · min/l) | 32.4 ± 3.0 | 36.5 ± 4.2 | 1.1 |
↵* p < 0.05 compared with control