Win-Shift | Saline Lever Selection | No-Lever Selection | Lever Selection Latency | FRF | % Responses on Selected Lever | Rate of Responding after Lever Selection | |||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose | Max | Dose | Min | D50 | Max | Med | Max | D50 | Max | Med | Max | D50 | Max | Med | Min | D50 | Max | Med | Min | D50 | Max | ||||||||||||||||
% | % | % | s | % | % | % | % | r/s | % | ||||||||||||||||||||||||||||
Antipsychotics | |||||||||||||||||||||||||||||||||||||
Haloperidol | 0.04 | 86 | 0.0025 | 86 | 0.28 | 57 | 0.31 | 530 | 0.22 | 86 | >0.63 | 11.3 | >0.63 | 17 | 0.04 | 95 | 0.0026 | 86 | 0.04 | 0.02 | 0.022 | 100 | |||||||||||||||
Raclopride | 0.04 | 71 | — | 100 | >0.16 | 29 | 0.16 | 270 | >0.16 | 29 | >0.16 | 10 | >0.16 | 0 | 0.04 | 80 | 0.027 | 100 | 0.02 | 0.014 | 0.018 | 100 | |||||||||||||||
Aripiprazole | 10 | 67 | 1.25 | 86 | >40 | 14 | 20 | 160 | 4.5 | 57 | >40 | 10.1 | >40 | 14 | 1.25 | 91 | 1.5 | 86 | 0.63 | 0.13 | 0.81 | 100 | |||||||||||||||
Olanzapine | 1.25 | 60 | 1.25 | 80 | 1.6 | 86 | 2.5 | 780 | 1.1 | 86 | >2.5 | 10 | >2.5 | 0 | 0.63 | 89 | 0.56 | 57 | 0.31 | 0.24 | 0.22 | 100 | |||||||||||||||
Ziprasidone | 10 | 60 | 10 | 80 | 17 | 57 | 5 | 540 | 2.5 | 100 | >20 | 11 | >20 | 29 | 1.25 | 89 | 0.97 | 71 | 0.08 | 0.088 | 0.75* | 100 | |||||||||||||||
Nemonapride | 0.01 | 57 | — | 100 | 0.03 | 86 | 0.02 | 780 | 0.026 | 86 | >0.04 | 11.1 | >0.04 | 29 | 0.01 | 97 | 0.0082 | 57 | 0.005 | 0.05 | 0.005 | 100 | |||||||||||||||
Thioridazine | 2.5 | 43 | 40 | 80 | >40 | 29 | 5 | 384 | 13 | 100 | 40 | 12.2 | >40 | 40 | 20 | 94 | 16 | 80 | 1.25 | 0.2 | 3.5 | 100 | |||||||||||||||
Chlorpromazine | 1.25 | 33 | 2.5 | 80 | 3.2 | 86 | 1.25 | 780 | 2.7* | 100 | >5 | 10.6 | >5 | 20 | 1.25 | 95 | 0.92 | 80 | 0.31 | 0.02 | 0.13 | 100 | |||||||||||||||
Clozapine | 1.25 | 29 | 0.16 | 86 | 9.2 | 57 | 5 | 650 | 4.5 | 100 | 5 | 11.6 | 4.5 | 57 | >10 | 92 | 3.5 | 57 | 1.25 | 0.63 | 1.8 | 100 | |||||||||||||||
Risperidone | 0.01 | 29 | 0.31 | 83 | 0.44 | 86 | 0.63 | 780 | 0.35 | 86 | >0.63 | 11 | >0.63 | 29 | >0.63 | 85 | >0.63 | 40 | 0.01 | 0.45 | 0.087 | 100 | |||||||||||||||
Potential antipsychotics | |||||||||||||||||||||||||||||||||||||
Bifeprunox | 2.5 | 100 | 10 | 80 | >10 | 29 | 0.04 | 300 | 7.1 | 57 | >10 | 11.4 | >10 | 20 | 0.04 | 87 | 0.02 | 100 | 0.01 | 0.21 | 0.02 | 100 | |||||||||||||||
F 15063 | 0.31 | 86 | — | 100 | 7.1 | 57 | 5 | 532 | 3.5 | 100 | >10 | 10.1 | >10 | 0 | 0.31 | 86 | 0.24 | 86 | 0.08 | 0.083 | 0.20 | 100 | |||||||||||||||
SLV313 | 0.04 | 86 | 0.08 | 83 | 0.14 | 57 | 0.16 | 530 | 0.1 | 86 | >0.31 | 10.6 | >0.31 | 14 | 0.08 | 93 | 0.24* | 86 | 0.04 | 0.19 | 0.03 | 100 | |||||||||||||||
SSR181507 | 0.63 | 71 | — | 100 | 6.0 | 71 | 2.5 | 740 | 1.4 | 100 | >10 | 10.5 | >10 | 17 | 0.63 | 88 | 0.38 | 83 | 0.16 | 0.29 | 0.27 | 100 | |||||||||||||||
Nonantipsychotics | |||||||||||||||||||||||||||||||||||||
(±)-8-Hydroxy-2-(di-n-propylamino)tetralin | 0.04 | 29 | 0.16 | 83 | 0.38 | 71 | 0.16 | 740 | 0.10 | 100 | >0.63 | 11.7 | >0.63 | 33 | >0.63 | 93 | >0.63 | 33 | 0.04 | 0.87 | 0.03 | 100 | |||||||||||||||
Phentolamine | 0.63 | 29 | — | 100 | >10 | 0 | >10 | 25 | >10 | 14 | >10 | 10 | >10 | 0 | >10 | 100 | >10 | 29 | 2.5 | 1.3 | 3.1 | 86 | |||||||||||||||
Chlorpheniramine | 0.63 | 29 | — | 100 | >10 | 0 | >10 | 26 | >10 | 14 | >10 | 10 | >10 | 0 | >10 | 100 | >10 | 29 | >10 | 1.7 | >10 | 29 | |||||||||||||||
Prazosin | 0.04 | 14 | 0.16 | 86 | >2.5 | 0 | 2.5 | 64 | >2.5 | 29 | >2.5 | 11 | >2.5 | 29 | >10 | 100 | >2.5 | 29 | 0.16 | 1.1 | <0.04 | 86 | |||||||||||||||
Propranolol | 0.63 | 14 | — | 100 | >10 | 0 | 2.5 | 37 | 8.4 | 57 | >10 | 10 | >10 | 0 | >10 | 97 | >10 | 29 | 10 | 1.4 | 4.2 | 86 | |||||||||||||||
Scopolamine | 0.01 | 14 | 0.63 | 40 | >2.5 | 43 | 0.16 | 580 | 0.07 | 100 | 0.16 | 14 | 0.09 | 75 | >2.5 | 83 | 0.05 | 75 | 0.04 | 0.18 | <0.01 | 100 | |||||||||||||||
Cocaine | 2.5 | 14 | — | 100 | >10 | 0 | 10 | 25 | 7.1 | 57 | >10 | 10.3 | >10 | 0 | >10 | 100 | >10 | 14 | >10 | 1.9 | >10 | 29 | |||||||||||||||
Naltrexone | 10 | 14 | 2.5 | 86 | >10 | 0 | >10 | 22 | >10 | 14 | >10 | 10 | >10 | 0 | >10 | 100 | >10 | 14 | 0.63 | 1.5 | 1.8 | 57 | |||||||||||||||
Diazepam | — | 0 | — | 100 | >10 | 29 | 10 | 310 | 3.0 | 100 | >10 | 10.2 | >10 | 0 | >10 | 99 | >10 | 40 | 10 | 0.81 | 3.0 | 100 | |||||||||||||||
Dizocilpine | — | 0 | 0.16 | 75 | 0.23 | 71 | 0.04 | 770 | <0.04 | 100 | 0.16 | 16.5 | 0.071 | 100 | 0.16 | 71 | 0.10 | 75 | 0.04 | 0.05 | <0.04 | 100 | |||||||||||||||
Ritanserin | — | 0 | — | 100 | >10 | 0 | >10 | 17 | >10 | 0 | >10 | 10 | >10 | 0 | >10 | 100 | >10 | 0 | >10 | 2.0 | >10 | 0 |
—, value could not be calculated