Monoamine levels in whole tissue of brain regions (nanogram/milligram protein)
Brain Regions | Genotypes (A3AR) | 5-HT | 5-HIAA | 5-HT/5-HIAA |
|---|---|---|---|---|
| Frontal cortex | +/+ | 5.32 ± 1.47 | 7.65 ± 4.17 | 0.57 ± 0.50 |
| –/– | 5.72 ± 0.80 | 12.11 ± 8.36 | 0.70 ± 0.43 | |
| Hippocampus | +/+ | 5.43 ± 1.73 | 8.96 ± 6.83 | 0.95 ± 0.55 |
| –/– | 5.84 ± 1.46 | 8.82 ± 4.42 | 0.78 ± 0.28 | |
| Midbrain | +/+ | 8.39 ± 0.98 | 13.84 ± 7.93 | 0.80 ± 0.42 |
| –/– | 9.29 ± 1.76 | 14.98 ± 6.00 | 0.68 ± 0.17 | |
| Striatum | +/+ | 6.19 ± 2.72 | 8.50 ± 5.68 | 0.87 ± 0.29 |
|
| –/– | 6.41 ± 1.71 | 9.21 ± 4.28 | 0.78 ± 0.22 |
| Brain Regions | Genotypes | DA | DOPAC | DA/DOPAC |
| Frontal cortex | +/+ | 13.51 ± 9.05 | 4.18 ± 2.96 | 3.38 ± 1.13 |
| –/– | 11.17 ± 4.88 | 2.93 ± 1.49 | 3.92 ± 0.74 | |
| Hippocampus | +/+ | 0.37 ± 0.18 | 0.10 ± 0.11 | 3.70 ± 1.53 |
| –/– | 0.36 ± 0.09 | 0.18 ± 0.13 | 2.00 ± 0.63 | |
| Midbrain | +/+ | 1.28 ± 0.22 | 0.70 ± 0.14 | 1.86 ± 0.30 |
| –/– | 1.39 ± 0.37 | 0.72 ± 0.09 | 1.90 ± 0.39 | |
| Striatum | +/+ | 83.47 ± 41.42 | 8.78 ± 5.39 | 10.27 ± 2.26 |
|
| –/– | 91.60 ± 43.07 | 9.63 ± 2.50 | 9.05 ± 3.81 |
| Brain Regions | Genotypes | NE | E |
|
| Frontal cortex | +/+ | 5.34 ± 1.03 | 0.14 ± 0.11 | |
| –/– | 5.07 ± 0.64 | 0.19 ± 0.14 | ||
| Hippocampus | +/+ | 5.04 ± 1.83 | 0.11 ± 0.06 | |
| –/– | 4.63 ± 1.57 | 0.20 ± 0.17 | ||
| Midbrain | +/+ | 7.88 ± 2.24 | 0.08 ± 0.08 | |
| –/– | 8.76 ± 3.29 | 0.32 ± 0.25 | ||
| Striatum | +/+ | 2.80 ± 0.66 | 0.13 ± 0.13 | |
|
| –/– | 2.02 ± 0.57 | 0.11 ± 0.08 |
|
NE, norepinephrine; E, epinephrine