TABLE 1

Time course renal excretory responses produced by the i.c.v. injection of N/OFQ in conscious, telemetered ICR-CD1 mice

Intracerebroventricular Treatment
1st h
2nd h
V
UNaV
UKV
CH2O
V
UNaV
UKV
CH2O
cc / h μEq / h μl / h cc / h μEq / h μl / h
Saline (n = 13) 0.07 ± 0.06 27 ± 16 29 ± 13 –0.93 ± 0.43 0.08 ± 0.04 27 ± 9 24 ± 4 –0.82 ± 0.09
N/OFQ, 0.03 nmol (n = 8) 0.20 ± 0.07 31 ± 4 46 ± 13 –1.35 ± 0.39 0.13 ± 0.05 20 ± 3 20 ± 6 –0.96 ± 0.23
N/OFQ, 0.3 nmol (n = 7) 0.29 ± 0.10 28 ± 17 28 ± 6 –0.99 ± 0.20 0.02 ± 0.02a 13 ± 13a 13 ± 13a –0.38 ± –0.38a
N/OFQ, 1 nmol (n = 14) 0.30 ± 0.06* 23 ± 6 33 ± 7 –1.02 ± 0.18 0.18 ± 0.05 29 ± 7 32 ± 8 –1.67 ± 0.31
N/OFQ, 3 nmol (n = 12)
0.34 ± 0.08*
20 ± 6
23 ± 4
–0.71 ± 0.08
0.31 ± 0.06*
36 ± 10
31 ± 10
–1.09 ± 0.28

  • ↵* , p < 0.05 compared with saline vehicle-treated group

  • ↵ a Only one of seven mice tested in this group excreted urine in the 2nd h