Parameter | NF (n = 5 Men) | DCM_NBB (n = 5 Men) |
---|---|---|
Tension | ||
Maximum (mN/mm2) | 21.4 ± 1.9 | 13.7 ± 1.5 * |
EC50 Ca2+ (μM) | 0.71 ± 0.07 | 0.43 ± 0.04* |
Actomyosin-ATPase activity | ||
Maximum (μM ADP/s) | 40.2 ± 2.2 | 45.4 ± 1.6 * |
EC50 Ca2+ (μM) | 0.64 ± 0.04 | 0.38 ± 0.02* |
Tension-dependent ATP consumption | ||
α [(μM ADP · s-1)/(mN · mm-2)] | 1.79 ± 0.03 | 3.67 ± 0.05* |
α, slope of the myosin-ATPase/tension relationship; EC50 Ca2+, Ca2+ concentration at which a 50% increase of tension or myosin-ATPase activity was achieved.
↵* p < 0.05 vs. NF.