Effects of inhibitors of MAPK pathways on TGFβ-induced reduction of BrdU incorporation
Data are shown as means ± S.E.M. of three experiments for pEC50, and maximum effects (percentage of inhibition) of the three TGFβ isoforms. None of the three inhibitors had statistically significant effects in a one-way ANOVA.
Inhibitor | pEC50 | ||||
| TGFβ1 | TGFβ2 | TGFβ3 | |||
| -log g/ml | |||||
| Control | 10.5 ± 0.3 | 10.4 ± 0.4 | 10.8 ± 0.6 | ||
| PD 98,059 | 10.3 ± 0.2 | 10.0 ± 0.2 | 10.4 ± 0.1 | ||
| SP 600,125 | 10.8 ± 0.2 | 10.6 ± 0.1 | 10.5 ± 0.4 | ||
| SB 203,580 | 10.5 ± 0.2 | 10.1 ± 0.5 | 10.8 ± 0.7 | ||
| Inhibitor |
E
max
| ||||
| TGFβ1 | TGFβ2 | TGFβ3 | |||
| % inhibition | |||||
| Control | 47.8 ± 6.6 | 53.8 ± 7.6 | 48.1 ± 8.9 | ||
| PD 98,059 | 50.6 ± 5.0 | 63.7 ± 6.9 | 45.8 ± 2.2 | ||
| SP 600,125 | 53.6 ± 3.7 | 56.4 ± 3.5 | 53.9 ± 8.3 | ||
| SB 203,580 | 45.8 ± 4.2 | 33.6 ± 6.8 | 39.0 ± 8.0 | ||