TABLE 2

Inhibition of chemokines in aerosolized CD86 ASO but not MM control oligonucleotide-treated allergic mice (100 μg/kg ASO treatment)

Cytokines and chemokines were quantitated by ELISA on day 67, 6 h after the second nebulized OVA challenge. Data are expressed as the group mean ± S.E., n = 4/group.

Cytokines/Chemokine
Naïve
Vehicle
CD86 ASO
MM ASO
IL-5 6.3 ± 1.8a,b 558 ± 104 413 ± 134 427 ± 97
IL-13 71 ± 10a 102 ± 5.8 87 ± 12 94 ± 9.7
Eotaxin 86 ± 17a,b 2932 ± 639 1082 ± 381a,b 1615 ± 575
RANTES
8.7 ± 2.1a
15.1 ± 2.8
8.9 ± 0.56a
15.1 ± 2.7

  • ↵ a p < 0.05 for groups compared with vehicle using Student's t test and Dunnett's test.

  • ↵ b p < 0.05 for groups compared with vehicle using Dunnett's test.