TABLE 1

Effects of phloretin on voltage-dependent inactivation of Ito

Mean inactivation values, determined experimentally (Fig. 9) in the presence and absence of phloretin, were fit to an equation of the form fractional current = 1 - A/(1 + e(Vm - V)/k), where A is a scaling factor; Vm is the voltage at half-maximal inactivation, V is voltage, and k is the voltage sensitivity of inactivation.




A

Vm

k
mV
Control 0.98 -56.2 3.2
Phloretin
0.94
-61.2
11.2