Patient | IC50 CLB Alone | IC50 NU7026 Alone | IC50 CLB + 1 μM NU7026 | I Value | IC50 CLB + 5 μM NU7026 | I Value | IC50 CLB + 10 μM NU7026 | I Value | ||
---|---|---|---|---|---|---|---|---|---|---|
μM | μM | μM | ||||||||
U1 | 16 ± 4.3 | 17 ± 3.2 | 11 ± 3.5 (1.4)a | 0.76 ± 0.17 | 6 ± 2.9 (2.6)a | 0.68 ± 0.10 | 3 ± 0.4 (4.6)a | 0.79 ± 0.14 | ||
U2 | 27 ± 3.7 | >100 | 23 ± 1.3 (1.2)a | 0.86 ± 0.14 | 12 ± 2.8 (2.2)a | 0.46 ± 0.21 | 4 ± 0.3 (7.6)a | 0.13 ± 0.03 | ||
U3 | 17 ± 3.1 | >100 | 17 ± 6.4 (1.0)a | 0.99 ± 0.19 | 17 ± 1.1 (1.0)a | 1.00 ± 0.12 | 13 ± 3.6 (1.4)a | 0.72 ± 0.16 | ||
U4 | 47 ± 5.4 | 41 ± 0.2 | 42 ± 4.9 (1.1)a | 0.92 ± 0.21 | 34 ± 6.4 (1.4)a | 0.84 ± 0.20 | 7 ± 1.3 (6.3)a | 0.40 ± 0.09 | ||
U5 | 25 ± 2.0 | 65 ± 4.7 | 29 ± 2.3 (0.9)a | 1.17 ± 0.16 | 26 ± 1.1 (1.0)a | 1.11 ± 0.18 | 11 ± 2.4 (2.2)a | 0.60 ± 0.06 | ||
U6 | 24 ± 6.3 | 67 ± 2.7 | 11 ± 3.2 (2.2)a | 0.47 ± 0.05 | 2.6 ± 0.3 (9.2)a | 0.18 ± 0.04 | 2.3 ± 0.8 (10.1)a | 0.25 ± 0.05 | ||
U7 | 52 ± 2.8 | 48 ± 5.6 | 29 ± 7.8 (1.8)a | 0.58 ± 1.13 | 19 ± 3.8 (2.7)a | 0.47 ± 0.07 | 17 ± 3 (3.0)a | 0.55 ± 0.03 | ||
U8 | 9 ± 0.8 | 20 ± 2.0 | 24 ± 2.3 (0.4)a | 2.73 ± 0.22 | 34 ± 1.5 (0.3)a | 4.05 ± 0.20 | 16 ± 4.1 (0.6)a | 2.27 ± 0.57 | ||
U9 | 44 ± 3.5 | >100 | 29 ± 1.4 (1.5)a | 0.65 ± 0.05 | 31 ± 2.8 (1.4)a | 0.71 ± 0.14 | 28 ± 1.3 (1.6)a | 0.63 ± 0.05 | ||
U10 | 61 ± 3.7 | 39 ± 4.8 | 25 ± 1.3 (2.5)a | 0.43 ± 0.04 | 9.6 ± 4.4 (6.4)a | 0.28 ± 0.02 | 6.8 ± 1.1 (9.0)a | 0.37 ± 0.01 | ||
U11 | 7.1 ± 2.3 | 20 ± 1.7 | 5.1 ± 1.0 (1.4)a | 0.77 ± 0.19 | 4.4 ± 0.9 (1.6)a | 0.87 ± 0.04 | 2.9 ± 0.07 (2.4)a | 0.92 ± 0.15 | ||
U12 | 32 ± 3.3 | 33 ± 3.9 | 22 ± 1.7 (1.5)a | 0.72 ± 0.02 | 13 ± 1.7 (2.5)a | 0.55 ± 0.01 | 12 ± 1.6 (2.7)a | 0.67 ± 0.01 | ||
U13 | 31 ± 3.1 | >100 | 26 ± 2.5 (1.2)a | 0.83 ± 0.14 | 27 ± 0.2 (1.1)a | 0.89 ± 0.07 | 21 ± 1.1 (1.4)a | 0.70 ± 0.11 | ||
U14 | 12 ± 2.8 | >100 | 5.9 ± 0.2 (2.1)a | 0.48 ± 0.12 | 8.8 ± 1.8 (1.4)a | 0.72 ± 0.18 | 6.3 ± 1.6 (1.9)a | 0.52 ± 0.02 | ||
T1 | 24 ± 5.5 | 24 ± 6.2 | 12 ± 3.4 (2.0)a | 0.54 ± 0.15 | 6.9 ± 1.4 (3.5)a | 0.49 ± 0.09 | 5.9 ± 1.9 (4.0)a | 0.66 ± 0.18 | ||
T2 | 59 ± 2.8 | >100 | 49 ± 5.2 (1.2)a | 0.84 ± 0.05 | 40 ± 2.7 (1.5)a | 0.68 ± 0.03 | 17 ± 4.5 (3.4)a | 0.30 ± 0.05 | ||
T3 | 32 ± 2.2 | >100 | 30 ± 3.1 (1.1)a | 0.95 ± 0.13 | 22 ± 3.7 (1.4)a | 0.70 ± 0.07 | 14 ± 1.3 (2.2)a | 0.45 ± 0.01 | ||
T4 | 43 ± 6.0 | >100 | 66 ± 5.8 (0.6)a | 1.54 ± 0.12 | 48 ± 12 (0.9)a | 1.11 ± 0.37 | 29 ± 2.3 (1.5)a | 0.67 ± 0.20 | ||
T5 | 16 ± 0.7 | >100 | 10 ± 0.8 (1.4)a | 0.71 ± 0.07 | 6.9 ± 0.4 (2.1)a | 0.48 ± 0.05 | 5.3 ± 1.0 (2.7)a | 0.37 ± 0.07 |
↵ a Ratio between CLB IC50 alone/CLB IC50 in the presence of NU7026.