TABLE 3

Potency of bicifadine and reference antinociceptive agents in models of acute inflammatory and visceral pain ED50 values presented as the mean, 95% confidence interval for the increase in withdrawal threshold (Randall-Selitto test), and decreasing the number of contractions/3 min (PPQ test).


Drug

Time after Administration

Randall-Selitto

PPQ Contractions
ED50
n/Dose
ED50
n/Dose
h mg / kg mg / kg
Bicifadine 1 9.2 (5.0–16.8) 8 13.2 (6–29) 5–10
Codeine 2 43 (29–62) 12 9.0 (7.4–11) 5–10
Acetaminophen
2
150 (98–231)
12
37 (11–123)
5–10