In vitro inhibition of LTA4H activity by JNJ-26993135
Assay | Activity | IC50 | n |
|---|---|---|---|
| nM | |||
| Recombinant human LTA4H enzyme | Epoxide hydrolase | 12 ± 10 | 7 |
| Aminopeptidase | 6 | 1 | |
| Ionophore-stimulated murine whole blood | LTB4 production | 339 ± 101 | 4 |
| LTC4 production | >30,000 | 1 | |
| LXA4 production | >30,000 | 3 | |
|
| PGE2 production | >30,000 | 2 |