TABLE 1
Summary of antagonistic activity, selectivity, and lipophilicity (log D7.4) of 4-(1-aryltriazol-4-yl)-tetrahydropyridine derivatives IC50 values (nanomolar) of compounds toward human mGluR1a and human mGluR5 are shown as mean ± S.E.M. from more than three individual experiments
mGluR1a | mGluR5 | Log D7.4 | ||
|---|---|---|---|---|
| Compound 1 | 9.8 ± 0.88 | 820 ± 170 | >4.0 |
|
| Compound 2 | 7.0 ± 1.2 | 170 ± 17 | 2.9 |
|
| FTIDC | 5.8 ± 0.49 | 6200 ± 520 | 2.1 |
|