ED50 values of selected treatments for drug-discrimination experiments ED50 values were calculated by nonlinear regression analysis using a sigmoidal dose-response curve with variable slope.
Drug | Dose Range Tested | ED50 (95% Confidence Interval) | Slope (95% Confidence Interval) | N Responding/N Testeda |
|---|---|---|---|---|
| mg / kg | ||||
| THC | 0.3–5.6 | 0.99 (0.87–1.10) | 1.88 (0.85–2.90) | 9/11 |
| THC + Nic 0.1b | 0.3–1.0 | 0.46 (0.18–0.75) | 1.01 (0.25–2.27) | 11/11 |
| THC + Piloc 1b | 0.3–1.0 | 0.50 (0.22–0.78) | 1.19 (0.17–2.54) | 8/9 |
| Mecam 3 + THC + Nic 0.1 | 0.3–1.0 | 0.93 (0.56–1.31) | 1.07 (0.12–2.25) | 10/10 |
| Scopol 0.03 + THC + Piloc 1 | 0.3–1.0 | 0.85 (0.58–1.12) | 1.48 (0.58–1.12) | 8/8 |
| Rim + THC + Nic 0.1 | 0.3–1.0 | 1.10 (0.81–1.39) | 1.86 (0.60–4.33) | 9/9 |
| Rim + THC + Piloc 1b | 0.3–1.0 | 0.53 (0.29–0.76) | 1.28 (0.04–2.64) | 9/9 |