Brain concentrations of DMI following 4 days of twice daily injections and 2 weeks of continual drug delivery
Values are means ± S.E.M. (n = 5-7).
Rat Age during Drug Delivery | 4 Days, Twice Daily Injections | 2 Weeks, Continual Drug Delivery | ||||||
|---|---|---|---|---|---|---|---|---|
| Adult | PND 9 to 12 | Adult | PND 21 to 35 | |||||
| DMI (mg/kg/day) | 20 | 4 | 7 | 10 | 15 | |||
| DMI (μg/g tissue) | 2.3 ± 0.3 | 1.0 ± 0.2 | 4.9 ± 0.3 | 0.60 ± 0.03 | 1.4 ± 0.2a | |||
| DDMI (μg/g tissue) | 2.5 ± 0.3 | 0.26 ± 0.04 | 0.65 ± 0.03 | 0.25 ± 0.02 | 0.54 ± 0.07a | |||
| Sum of DMI and DDMI | 4.8 | 1.3 | 5.5 | 0.85 | 1.9 | |||
| Ratio DDMI/DMI | 1.1 | 0.26 | 0.12 | 0.42 | 0.39 | |||