Resting cardiovascular variables before administration of THC or its vehicle
Data are given as mean ± S.E.M.
Administration Protocol | Heart Rate | Blood Pressure | Vascular Conductance | ||||
|---|---|---|---|---|---|---|---|
| Renal | Mesenteric | Aortic | |||||
| beat min-1 | mm Hg | (kHz mm Hg-1)103 | |||||
| Control rats | |||||||
| Vehicle and THC (n = 9) | 343 ± 8 | 110 ± 2 | 85 ± 9 | 59 ± 5 | 39 ± 5 | ||
| Vehicle and vehicle (n = 9) | 347 ± 11 | 110 ± 3 | 79 ± 8 | 59 ± 7 | 40 ± 2 | ||
| AM251 and THC (n = 8) | 360 ± 11 | 112 ± 3 | 77 ± 7 | 57 ± 8 | 40 ± 4 | ||
| AM251 and vehicle (n = 9) | 352 ± 10 | 111 ± 2 | 80 ± 7 | 56 ± 6 | 40 ± 4 | ||
| l-NAME-treated rats | |||||||
| Vehicle and THC (n = 9) | 331 ± 6 | 132 ± 3* | 74 ± 6 | 44 ± 3* | 30 ± 3 | ||
| Vehicle and Vehicle (n = 9) | 332 ± 9 | 129 ± 3* | 72 ± 4 | 48 ± 4 | 30 ± 3* | ||
| AM251 and THC (n = 8) | 341 ± 10 | 125 ± 3* | 78 ± 4 | 50 ± 4 | 38 ± 4 | ||
| AM251 and Vehicle (n = 9) | 326 ± 10 | 125 ± 3* | 78 ± 5 | 52 ± 4 | 36 ± 5 | ||
↵* Significant difference between control and l-NAME-drinking animals in resting variables before administration of drugs (Mann-Whitney test).