TABLE 1

pEC50 values in G3 vessels from control and l-NAME-treated animals




Water-Drinking Controls

l-NAME-Treated
Acetylcholine 7.64 ± 0.17 7.81 ± 0.13
Verapamil 7.53 ± 0.19 7.72 ± 0.25
THC 5.58 ± 0.12 6.13 ± 0.13*
THC and AM251 5.87 ± 0.21 6.02 ± 0.16
THC and capsaicin 4.68 ± 0.30 4.55 ± 0.25
THC and indomethacin
5.82 ± 0.26
5.14 ± 0.20*
  • * Significant difference between the control and l-NAME treated animals.

  • Significant difference from control THC pEC50 values within each group.