TABLE 3

Relative potencies of β-AR agonists in relaxing carbachol-precontracted human bladder strips

Each strip was precontracted with 10-7 M carbachol. EC50 values represent the mean and 95% confidence limit. Maximal relaxation values represents the mean ± S.E. Values in brackets indicate the efficacy ratio to YM178.

Agonist
EC50
95% CL
Maximal Relaxation
μM %
YM178, n = 6 0.78 [1] 0.32-1.9 89.4 ± 2.3
Isoproterenol, n = 4 0.28 [3] 0.051-1.5 85.6 ± 2.7
CGP-12177A, n = 5
>100 [<1/130]
N.D.
48.2 ± 7.2

  • N.D., not detected.