Memantine, Ro 25-6981, and CP-101,606 inhibit SD generation and amplitude
To indicate dose dependency, Pearson correlation coefficients were as follows: memantine, r = -0.92 (p = 0.04); CP-101,606, r = -0.97 (p = 0.01); Ro 25-6981, r = -0.76 (p = 0.12). Control vehicles are 0.9% (w/v) saline for memantine and Ro 25-6981 and Kleptose for CP-101,606. Values are means ± S.D., and they are expressed as event number in millivolts (SD events) and as percentage increase compared with the baseline (cortical CBFLDF and pO2, calculated as 100%). For other details, see Table 1.
Treatment | SD Event No. | ||||||
|---|---|---|---|---|---|---|---|
| d.c. Potential | CBFLDF | pO2 | n | ||||
| mV | rBPU | mm Hg | |||||
| Saline | 7.67 ± 1.75 | 7.00 ± 2.00 | 7.00 ± 2.00 | 6 | |||
| Kleptose | 7.17 ± 1.17 | 7.00 ± 1.23 | 7.17 ± 1.17 | 6 | |||
| Memantine (10 mg/kg i.p.) | 2.00 ± 1.79***,†† | 2.00 ± 1.79** | 1.67 ± 1.86** | 6 | |||
| Memantine (3 mg/kg i.p.) | 4.17 ± 1.94** | 3.50 ± 2.07* | 2.50 ± 2.38* | 4-6 | |||
| Memantine (1 mg/kg i.p.) | 5.33 ± 0.52 | 4.17 ± 1.72 | 2.75 ± 1.71* | 4-6 | |||
| Ro 25-6981 (10 mg/kg i.p.) | 4.50 ± 1.64** | 4.17 ± 1.84† | 3.00 ± 2.97* | 6 | |||
| Ro 25-6981 (3 mg/kg i.p.) | 5.00 ± 1.41* | 4.67 ± 1.37 | 3.50 ± 2.26 | 6 | |||
| Ro 25-6981 (1 mg/kg i.p.) | 5.67 ± 1.21 | 5.00 ± 1.23 | 5.00 ± 0.82 | 4-6 | |||
| CP-101,606 (10 mg/kg i.p.) | 2.33 ± 1.97***,†† | 1.33 ± 0.82***,†††,¶ | 1.17 ± 1.60***,†† | 6 | |||
| CP-101,606 (3 mg/kg i.p.) | 4.67 ± 1.21* | 4.33 ± 1.86* | 3.00 ± 2.28** | 6 | |||
| CP-101,606 (1 mg/kg i.p.) | 6.33 ± 1.63 | 6.25 ± 1.50 | 5.75 ± 2.22 | 4-6 | |||
|
| SD Event Amplitude | ||||||
| mV | Increase % | ||||||
| Saline | 14.9 ± 2.8 | 180.2 ± 24.2 | 203.6 ± 76.0 | 6 | |||
| Kleptose | 16.7 ± 2.0 | 205.3 ± 18.5 | 139.1 ± 15.4 | 6 | |||
| Memantine (10 mg/kg i.p.) | 7.52 ± 4.4** | 162.8 ± 35.8 | 125.4 ± 27.4 | 6 | |||
| Memantine (3 mg/kg i.p.) | 10.4 ± 1.6 | 150.6 ± 23.0 | 177.9 ± 102 | 4-6 | |||
| Memantine (1 mg/kg i.p.) | 11.6 ± 4.0 | 151.3 ± 19.5 | 206.2 ± 95.3 | 4-6 | |||
| Ro 25-6981 (10 mg/kg i.p.) | 9.21 ± 5.82 | 180.7 ± 41.4 | 191.6 ± 158 | 6 | |||
| Ro 25-6981 (3 mg/kg i.p.) | 9.69 ± 3.33 | 209.3 ± 40.7 | 153.5 ± 42.1 | 6 | |||
| Ro 25-6981 (1 mg/kg i.p.) | 12.1 ± 7.3 | 213.5 ± 63.7 | 169.1 ± 42.4 | 4-6 | |||
| CP-101,606 (10 mg/kg i.p.) | 7.29 ± 5.42** | 160.7 ± 54.7 | 116.1 ± 31.1† | 6 | |||
| CP-101,606 (3 mg/kg i.p.) | 9.67 ± 4.48* | 201.5 ± 39.9 | 125.7 ± 29.7 | 6 | |||
| CP-101,606 (1 mg/kg i.p.) | 9.03 ± 2.66* | 183.1 ± 35.4 | 196.3 ± 80.5 | 4-6 | |||