Parameter estimates of the final population PK model for norbuprenorphine
Population Estimate | CV of Parameter Estimate | Interanimal Variability | CV of Variability Estimate | |
|---|---|---|---|---|
| % | % | % | ||
| Vmk40, min-1 | 0.246 | 20.1 | 13.4 | 43.0 |
| Kmk40, ng/ml | 331 | 29.7 | N.E. | |
| K45, min-1 | 0.050 | 41.8 | ||
| k54, min-1 | 0.002 | 44.3 | ||
| K46, min-1 | 0.219 | 15.8 | ||
| k64, min-1 | 0.036 | 10.1 | 28.1 | 34.4 |
| V4, ml | 218 | 15.8 | ||
| Proportional error, % | 22.8 | 11.9 |
|
|
CV, coefficient of variation; N.E., not estimated.