TABLE 1

Effect of zinc pyrithione on myocardial recovery after 15- and 30-min ischemia

Preischemia
Reperfusion
Control
10-5 M Zinc Pyrithione
Control
10-5 M Zinc Pyrithione
15-Min ischemia
    LVDP (mm Hg) 94.73 ± 4.59a 101.01 ± 5.83 77.98 ± 18.39 102.98 ± 13.79
    Heart Rate (beats/min) 233.06 ± 36.66 262.10 ± 9.28 241.56 ± 31.79 281.26 ± 7.41
    dP/dT max (mm Hg/s) 3844.45 ± 339.53 4222.83 ± 479.19 1861.30 ± 507.31 4496.80 ± 262.50b
    RPP (mm Hg/beats/min) 22,087.41 ± 3665.29 26,404.04 ± 627.61 20,361.14 ± 6457.16 29,092.80 ± 4544.96
30-Min ischemia
    LVDP (mm Hg) 112.55 ± 2.12 103.01 ± 9.77 19.48 ± 6.92 82.65 ± 11.98c
    Heart rate (beats/min) 235.44 ± 6.05 194.59 ± 24.67 101.79 ± 44.86 179.84 ± 32.73
    dP/dT max (mm Hg/s) 3276.37 ± 301.03 3953.34 ± 591.76 160.05 ± 141.21 3259.24 ± 223.41c
    RPP (mm Hg/beats/min)
26,506.88 ± 921.28
19,734.22 ± 2754.72
2892.86 ± 1784.34
15,268.77 ± 4185.71c

  • ↵ a The data are mean values ± S.D. taken from five to six hearts at 30-min reperfusion.

  • ↵ b p < 0.05.

  • ↵ c p < 0.01 in comparison with the values obtained after reperfusion in control conditions.