TABLE 3

Pressure-volume relationships

All data are mean ± S.E.M.

Baseline
CHF
12 Weeks
Ees (mm Hg/ml)
    Control 7.20 ± 0.99 4.66 ± 0.83a 4.06 ± 1.24ab
    Meto 8.80 ± 1.26 5.27 ± 1.42 4.21 ± 0.92ab
    Cilo (low) 5.05 ± 1.45 2.29 ± 0.51 3.42 ± 1.06
    Cilo (high) 7.35 ± 1.36 3.56 ± 0.89a 4.30 ± 0.79
V0 (ml)
    Control 38.6 ± 5.6 45.2 ± 10.1 48.0 ± 10.0
    Meto 37.7 ± 7.8 35.3 ± 10.0 34.0 ± 12.2
    Cilo (low) 36.6 ± 13.7 24.5 ± 18.2 55.1 ± 7.4
    Cilo (high) 22.7 ± 4.1 26.2 ± 10.5 29.1 ± 12.8
α
    Control 0.045 ± 0.014 0.040 ± 0.008 0.063 ± 0.020
    Meto 0.022 ± 0.004 0.060 ± 0.031 0.029 ± 0.009
    Cilo (low) 0.047 ± 0.021 0.018 ± 0.002 0.016 ± 0.008
    Cilo (high) 0.033 ± 0.010 0.047 ± 0.021 0.027 ± 0.006
β
    Control 2.98 ± 2.10 1.54 ± 1.34 0.63 ± 0.46
    Meto 4.23 ± 1.14 2.30 ± 1.36 4.17 ± 1.86
    Cilo (low) 2.03 ± 1.66 2.77 ± 0.68 8.06 ± 4.32
    Cilo (high) 4.77 ± 3.38 2.56 ± 1.58 5.05 ± 3.83
τ (ms)
    Control 19 ± 5 28 ± 6 40 ± 8
    Meto 28 ± 8 34 ± 7 23 ± 7
    Cilo (low) 34 ± 9 48 ± 12 36 ± 9
    Cilo (high)
36 ± 5
39 ± 3
37 ± 5

  • Ees, end-systolic elastance; V0, volume-axis intercept; α, chamber stiffness constant; β, scaling constant; τ, isovolemic relaxation constant.

  • ↵ a p < 0.05 vs. baseline.

  • ↵ b p < 0.05 vs. CHF.