TABLE 1

Hemodynamics

All data are mean ± S.E.M.

	Baseline	CHF	12 Weeks
LVSP (mm Hg)
Control	127 ± 7	110 ± 3^a	115 ± 5
Meto	124 ± 2	108 ± 4^a	121 ± 3^b
Cilo (low)	130 ± 3	113 ± 3^a	121 ± 4^b
Cilo (high)	125 ± 3	102 ± 3^a	120 ± 1^b
LVEDP (mm Hg)
Control	9.5 ± 0.6	22.5 ± 1.4^a	20.2 ± 3.1^a
Meto	9.2 ± 1.4	20.0 ± 1.4^a	15.2 ± 2.9
Cilo (low)	10.2 ± 0.9	22.8 ± 3.4^a	18.8 ± 1.2^a
Cilo (high)	13.0 ± 2.1	21.0 ± 1.2^a	16.0 ± 3.8
MAP (mm Hg)
Control	103 ± 5	88 ± 3^a	89 ± 5^a
Meto	104 ± 3	91 ± 1^a	94 ± 1
Cilo (low)	104 ± 2	92 ± 2^a	98 ± 3
Cilo (high)	100 ± 3	84 ± 2^a	101 ± 2^b ^c

↵ a p < 0.05 vs. baseline.
↵ b p < 0.05 vs. CHF.
↵ c p < 0.05 vs. control.