TABLE 4

Histological assessment of forepaws in the collagen-induced arthritis experiments with prophylactic or therapeutic dosing of VX-765

Group	No. of Joints	Histological Score^a	No. of Joints with Cartilage Erosion	No. of Joints with Bone Changes
Prophylactic dosing experiment
Vehicle	9	1.83 ± 0.50	9	0
VX-765, 25 mg/kg	10	1.50 ± 0.58	4	0
VX-765, 50 mg/kg	8	1.25 ± 0.42^*	2	0
VX-765, 100 mg/kg	9	1.13 ± 0.35^*	1	0
Therapeutic dosing experiment
Vehicle	7	2.93 ± 1.02	7	4
VX-765, 10 mg/kg	10	1.70 ± 0.54^*	7	1
VX-765, 25 mg/kg	9	1.22 ± 0.44^*	2	0
VX-765, 50 mg/kg	10	1.15 ± 0.34^*	2	0
VX-765, 100 mg/kg	9	1.11 ± 0.22^*	2	0
Prednisolone	10	1.20 ± 0.35^*	3	0