Ki values for VRT-043198 against caspases and noncaspase proteases
Caspases | Noncaspase Proteases | ||||
|---|---|---|---|---|---|
| Enzyme | Ki | Enzyme | Ki | ||
| nM | nM | ||||
| Caspase-1 (ICE) | 0.8 | Granzyme B | 9000 | ||
| Caspase-4 | <0.6 | Cathepsin B | 48% inhibition at 100 μM | ||
| Caspase-8 | 100 | Trypsin | 4% inhibition at 100 μM | ||
| Caspase-6 | 560 | ||||
| Caspase-9 | 1030 | ||||
| Caspase-7 | 16,000 | ||||
| Caspase-3 | 21,500 |
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