TABLE 5

Pharmacokinetic parameters for 4-OH-CPA formation

Plasma 4-OH-CPA levels (see Fig. 4) were used to calculate pharmacokinetic parameters. Values are mean ± S.E. (n = 11 for wild-type group and n = 7 for the other groups). Tukey's test was used for statistical analysis.

Strain
Tmax
Cmax
t1/2
AUCINF
min μg / ml min μg · min / ml
Wild type 23.2 ± 1.8 2.6 ± 0.3 28.1 ± 3.0 139 ± 15
LCN 45.0 ± 7.1a 1.2 ± 0.1a 70.4 ± 6.1a 168 ± 11
CL 25.0 ± 0.0 2.9 ± 0.3 31.9 ± 2.7 191 ± 27
CL-LCN
48.6 ± 13.4b
1.0 ± 0.1a
96.7 ± 11.9a
163 ± 7

  • ↵ a P < 0.01, compared with wild type.

  • ↵ b P < 0.05, compared with wild type.