TABLE 1
Inhibitory effect of 1 μM NS-398 on the vasoconstrictor response to phenylephrine in aortic segments from normotensive (WKY) and hypertensive (SHR) rats untreated or treated for 12 weeks with 15 mg/g · day losartan or 44 and 9.4 mg/kg · day HH, respectively
The effect of NS-398 in aortic segments from WKY preincubated with 0.1 μM Ang II for 6 h is also shown. Results are expressed as percentage of inhibition of the maximum response to phenylephrine induced by NS-398 in each case. Number of animals (n) used is in parentheses.