Inhibitory effect of 1 μM NS-398 on the vasoconstrictor response to phenylephrine in aortic segments from normotensive (WKY) and hypertensive (SHR) rats untreated or treated for 12 weeks with 15 mg/g · day losartan or 44 and 9.4 mg/kg · day HH, respectively
The effect of NS-398 in aortic segments from WKY preincubated with 0.1 μM Ang II for 6 h is also shown. Results are expressed as percentage of inhibition of the maximum response to phenylephrine induced by NS-398 in each case. Number of animals (n) used is in parentheses.
WKY | SHR | |
|---|---|---|
| Untreated | 33.5 ± 2.2 (12) | 58.3 ± 6.4 (14)* |
| Losartan | 25.7 ± 6.9 (10) | 9.9 ± 4.4 (17)# |
| HH | 53.2 ± 7.7 (10) | |
| Ang II preincubation | 45.2 ± 5.9 (7)# |
|