ED50 values of selected treatments for drug discrimination experiments
Drug | Route | Dose Range Tested | ED50 (95% Confidence Interval) | n Responding/ n Testeda |
|---|---|---|---|---|
| mg / kg | ||||
| THC | i.p. | 0.3-1.0 | 0.59 (0.42-0.75) | 12/12 |
| THC | i.p. | 0.3-3.0 | 0.48 (0.22-0.73) | 6/12 |
| THC | i.v. | 0.03-0.3 | 0.074(0.04-0.10) | 10/10 |
| AEA | i.v. | 1-10 | N/A | 3/11 |
| Methanandamide | i.v. | 0.3-3.0 | 1.10 (0.84-1.37) | 11/11 |
| URB 0.3 + AEA | i.p.+ i.v. | 0.3-3.0 | 0.49 (0.09-0.72) | 7/12 |
| Rim 3 + URB 0.3 + AEA | i.p.+ i.v. | 0.3-3.0 | 2.55 (0.89-4.38) | 9/12 |
| Rim 3 + methanandamide | i.p.+ i.v. | 0.3-3.0 | 3.23 (2.42-4.04) | 12/12 |
| URB 0.3 + AEA | i.p.+ i.p. | 3-10 | 3.26 (2.71-3.81) | 6/6 |
N/A, not applicable; URB, URB-597.
↵ a Refers to the highest dose tested.