Resting cardiovascular variables
Values (mean ± S.E.M.) are those obtained prior to administration of the peptide, 90 min after the onset of saline or atropine plus propranolol (ATR + PROP; experiment 1) or 15 min after administration of mepyramine plus cimetidine (MEP + CIM; experiment 2).
Experiment 1 | Saline UCN1 (n = 8) | ATR + PROP UCN1 (n = 8) | Saline SRP (n = 8) | ATR + PROP SRP (n = 8) |
| Heart rate (beats/min) | 316 ± 6 | 341 ± 12 | 326 ± 6 | 347 ± 12 |
| Mean blood pressure (mm Hg) | 107 ± 2 | 111 ± 2 | 111 ± 3 | 112 ± 3 |
| Renal VC ([kHz/mm Hg]103) | 72 ± 4 | 77 ± 6 | 80 ± 4 | 79 ± 8 |
| Mesenteric VC ([kHz/mm Hg]103) | 57 ± 4 | 56 ± 7 | 54 ± 4 | 56 ± 9 |
| Hindquarters VC ([kHz/mm Hg]103) | 30 ± 4 | 41 ± 3 | 36 ± 3 | 43 ± 3 |
| Experiment 2 | Saline UCN1 (n = 6) | MEP + CIM UCN1 (n = 6) | Saline SRP (n = 5) | MEP + CIM SRP (n = 5) |
| Heart rate (beats/min) | 343 ± 9 | 303 ± 12 | 316 ± 10 | 307 ± 13 |
| Mean blood pressure (mm Hg) | 111 ± 2 | 111 ± 3 | 115 ± 9 | 107 ± 6 |
| Renal VC ([kHz/mm Hg]103) | 80 ± 7 | 86 ± 11 | 89 ± 8 | 94 ± 11 |
| Mesenteric VC ([kHz/mm Hg]103) | 63 ± 4 | 68 ± 6 | 58 ± 4 | 54 ± 4 |
| Hindquarters VC ([kHz/mm Hg]103) | 37 ± 3 | 35 ± 6 | 37 ± 1 | 39 ± 2 |
VC, vascular conductance.