Characteristics of the PI3K family
PI3K Family | Catalytic Molecule | Regulatory Molecule | In Vitro Substrate | Distribution | |
|---|---|---|---|---|---|
| Ia | PI3Kα | p110α | p85α, p85β | PtdIns | Ubiquitous |
| PI3Kβ | p110β | p55γ | PtdIns(4)P | Ubiquitous | |
| PI3Kδ | p110δ | p85α, p85β | PtdIns(4,5)P2 | Whole blood, thymus | |
| Ib | PI3Kγ | p110γ | p101 | PtdIns(4,5)P2 | Whole blood, thymus |
| p84/p87FIKAP | |||||
| II | C2α | Clathrin | PtdIns | Widely expressed | |
| PtdIns(4)P | |||||
| C2b | Clathrin | PtdIns | Widely expressed | ||
| C2b | Clathrin | PtdIns | Prostate, Liver, Breast | ||
| III | Vps34p | Vps15p (p150) | PtdIns | Ubiquitous, | |
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| Beclin 1 |
| Constitutive |