Effects of albumin preparations on the kinetics of 4-methylumbelliferone glucuronidation by recombinant UGT2B7
Data represent the mean of duplicate estimations. BSA and HAS are unmodified (or crude).
Parameter | No Albumin | BSA | HSA | HSA-FAF | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.1% | 1.0% | 2.0% | 0.1% | 1.0% | 2.0% | 0.1% | 1.0% | 2.0% | ||||||||
| S50 | 462 | 311 | 246 | 213 | 432 | 375 | 426 | 314 | 164 | 102 | ||||||
| n | 1.6 | 1.5 | 1.6 | 1.6 | 1.5 | 1.7 | 1.5 | 1.6 | 1.7 | 2.1 | ||||||
| Vmax, pmol/min ยท mg | 1065 | 1115 | 1140 | 1195 | 1221 | 848 | 990 | 1329 | 1226 | 1093 | ||||||
| CLmax, l/h (calculated according to equation under Data Analysis) | 2.31 | 3.58 | 4.63 | 5.61 | 2.82 | 2.26 | 2.32 | 4.23 | 7.47 | 10.71 | ||||||