Uptake clearances and plasma concentration of protein and S-nitroso moieties at 120 min after injection of S-nitrosylated and native proteins
Uptake Clearance | Plasma Concentration after 120 Min | |||||||
|---|---|---|---|---|---|---|---|---|
| Liver | Kidney | Carrier | S-NO | S-NO/Carrier | ||||
| ml/h | % of injected dose | |||||||
| HSA | ||||||||
| NO (–) | 222 ± 20a | 48 ± 18 | 62.6 ± 4.4 | |||||
| NO (+) | 168 ± 14 | 126 ± 14 | 63.4 ± 7.2 | 34.6 ± 8.0 | 54.6 ± 4.2 | |||
| R410C | ||||||||
| NO (–) | 324 ± 12 | 408 ± 17 | 36.2 ± 4.0 | |||||
| NO (+) | 150 ± 13 | 444 ± 25 | 42.2 ± 4.7 | 29.3 ± 5.5 | 69.4 ± 5.3 | |||
↵ a Results are expressed as mean ± S.E.M. (n = 3)