Summary of data obtained with dopamine, RGH-237, BP-897, and SB-277011-A in the in vitro [35S]GTPγS binding assay Data are means ± S.D. values. Numbers in parentheses represent the number of measurements.
hD2L | hD3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Emax | EC50 | IC50 | Emax | EC50 | IC50 | |||||
| % | nM | % | nM | |||||||
| Dopamine | 100 (24) | 426 ± 222 (24) | 100 (24) | 130 ± 77 (50) | ||||||
| RGH-237 | 54 ± 8.3 (3) | 346 ± 191 (3) | n.d. | 52 ± 9.0 (3) | 8.7 ± 7.6 (3) | 28 (1) | ||||
| BP-897 | 6 (1) | 94 (1) | 4.6 ± 1.9 (2) | 8.9 ± 11 (2) | ||||||
| SB-277011-A | n.d. | n.d. | 8718 ± 2474 (3) | –16 ± 12 (2) |
| 72 ± 52 (2) | ||||
N.D., not determined