Baseline hemodynamic and renal data by study day
Parameter | Acute | Chronic | ||||
|---|---|---|---|---|---|---|
| Valsartan | Valsartan + HOE-140 | Valsartan | Valsartan + HOE-140 | |||
| MAP (mm Hg) | ||||||
| Normotensive | 82.4 ± 8.6 | 84.1 ± 9.4 | 75.5 ± 7.4* | 75.1 ± 8.5* | ||
| Hypertensive | 100.2 ± 8.4† | 98.2 ± 7.6† | 91.1 ± 8.8*† | 92.0 ± 7.4*† | ||
| Heart rate (bpm) | ||||||
| Normotensive | 63.0 ± 10.5 | 64.1 ± 8.9 | 62.6 ± 8.0 | 63.8 ± 9.6 | ||
| Hypertensive | 68.1 ± 6.9 | 67.6 ± 8.8 | 67.5 ± 10.0 | 68.9 ± 12.6 | ||
| RVR (mm Hg/[ml/min/1.73 M2]) | ||||||
| Normotensive | 0.129 ± 0.026 | 0.122 ± 0.020 | 0.115 ± 0.021 | 0.109 ± 0.022 | ||
| Hypertensive | 0.162 ± 0.039‡ | 0.166 ± 0.036§ | 0.132 ± 0.032 | 0.135 ± 0.036* | ||
| 24-h Urine sodium (mmol) | ||||||
| Normotensive | 18.4 ± 9.8 | 17.6 ± 14.4 | 21.3 ± 15.2 | 25.6 ± 22.2 | ||
| Hypertensive | 39.8 ± 55.6 | 28.2 ± 11.9 | 33.8 ± 16.2 | 30.7 ± 18.8 | ||