Estimated pharmacokinetic and pharmacodynamic parameters
Parameter | Final Estimate | CV% |
|---|---|---|
| Pharmacokinetic parameters | ||
| ka (min–1) | 0.02 | 4.96 |
| Vmax (μg/min/kg) | 5324 | 6.89 |
| Km (μg/ml) | 579 | 12.5 |
| CLin (ml/min/kg) | 0.01 | 20.1 |
| CLout (ml/min/kg) | 0.06 | 19.7 |
| Vp (ml/kg) | 458 | 2.47 |
| VECF (ml/kg) | 1.16a | –c |
| F | 0.92a | –c |
| Pharmacodynamic parameters | ||
| kin | 3.28b | –c |
| kout (min–1) | 0.03 | 40.0 |
| Imax | 0.51 | 22.4 |
| IC50, acute (μg/ml) | 12.7 | 103 |
| IC50, chronic (μg/ml) | 99.1 | 46.3 |