TABLE 2

In vitro and in vivo activity of NRI and SRI compounds IC50 values were determined using nine concentrations in triplicate. Values shown are mean ± S.E.M. (n = 3).


Compound

SERT IC50

NET IC50

Maximal % Effect

ED30
nM mg/kg
S,S-Reboxetine 2000 ± 178 1 ± 0.03 93 0.68
Duloxetine 15 ± 1.6 20 ± 2.8 63 2.54
WY-X1 30 ± 3.2 13 ± 3.4 65 1.8
WY-X2 21 ± 2.1 31 ± 3.3 68 2.77
WY-X3
534 ± 28
32 ± 3.3
89
2.81