TABLE 1

Differential in vitro functional activity of commercial SRI and NRI compounds IC50 values were determined using nine concentrations in triplicate. Values shown are mean ± S.E.M. (n = 3).


Compound

IC50

NET / SERT
SERT
NET
-Fold Separation
nM
Paroxetine 3 ± 1 173 ± 25 0.02
Fluoxetine 32 ± 3 1002 ± 170 0.03
Desipramine 313 ± 47 9 ± 1 35
Reboxetine
344 ± 44
10 ± 1
35