TABLE 3

Behaviors elicited after acute and repeated drug administration


Drug (Dose)

Incidence of Grooming

Incidence of Sniffing

Incidence of Rearing
Injection 1
Injection 4
Injection 1
Injection 4
Injection 1
Injection 4
Vehicle 22.67 ± 1.81 30.87 ± 3.9 63.33 ± 2.63 58.87 ± 3.42 25.27 ± 1.83 20.13 ± 2.13
Morphine (15 mg/kg) 2.38 ± 1.18* 5.38 ± 0.94* 62.75 ± 1.52 69.75 ± 2.17 3.75 ± 0.70* 9.75 ± 1.73*
SR 16435 (10 mg/kg) 1.13 ± 0.88* 0.0 ± 0.0* 0.25 ± 0.26* 0.0 ± 0.0* 1.38 ± 1.02* 0.63 ± 0.50*
SR 16435 (30 mg/kg) 0.50 ± 0.33* 0.25 ± 0.25* 0.13 ± 0.13* 2.00 ± 2.00* 1.13 ± 0.88* 0.50 ± 0.50*
SR 16435 (10 mg/kg) + Naloxone (1 mg/kg)
26.75 ± 5.34
30.14 ± 2.64
59.00 ± 2.69
54.71 ± 3.27
26.25 ± 3.59
17.14 ± 2.11
  • * Significant difference from vehicle controls (p < 0.05, Student Newman-Keuls test).

  • Significant difference from first injection (p < 0.05, Student Newman-Keuls test).