Drug (Dose) | Incidence of Grooming | Incidence of Sniffing | Incidence of Rearing | ||||||
---|---|---|---|---|---|---|---|---|---|
Injection 1 | Injection 4 | Injection 1 | Injection 4 | Injection 1 | Injection 4 | ||||
Vehicle | 22.67 ± 1.81 | 30.87 ± 3.9 | 63.33 ± 2.63 | 58.87 ± 3.42 | 25.27 ± 1.83 | 20.13 ± 2.13 | |||
Morphine (15 mg/kg) | 2.38 ± 1.18* | 5.38 ± 0.94* | 62.75 ± 1.52 | 69.75 ± 2.17 | 3.75 ± 0.70* | 9.75 ± 1.73*† | |||
SR 16435 (10 mg/kg) | 1.13 ± 0.88* | 0.0 ± 0.0* | 0.25 ± 0.26* | 0.0 ± 0.0* | 1.38 ± 1.02* | 0.63 ± 0.50* | |||
SR 16435 (30 mg/kg) | 0.50 ± 0.33* | 0.25 ± 0.25* | 0.13 ± 0.13* | 2.00 ± 2.00* | 1.13 ± 0.88* | 0.50 ± 0.50* | |||
SR 16435 (10 mg/kg) + Naloxone (1 mg/kg) | 26.75 ± 5.34 | 30.14 ± 2.64 | 59.00 ± 2.69 | 54.71 ± 3.27 | 26.25 ± 3.59 | 17.14 ± 2.11 |