TABLE 3

The p values for the main effect of monoamine releaser dose and reinforcer type (cocaine or food) and for the dose-reinforcer interaction from two-factor analysis of variance of monoamine releaser effects on cocaine self-administration and food-maintained responding

Analyses were conducted on data shown in Figs. 2 and 4. Data for PAL-287 were reported in Rothman et al. (2005).

Drug
Main Effect of Dosea
Main Effect of Reinforcera
Dose-Reinforcer Interactiona
PAL-353
    0.01 Coc <0.001 0.008 0.002
    0.032 Coc 0.076 0.030 0.076
Methamphetamine
    0.01 Coc <0.001 0.002 <0.001
    0.032 Coc 0.013 0.008 0.013
PAL-314 0.32 0.15 0.25
PAL-287 <0.001 0.114 0.116
Fenfluramine
0.001
0.40
0.43

  • Coc, cocaine.

  • ↵ a All significant effects (p < 0.05) are shown in boldface.