ED50s and potency ratios for Δ9-THC and AJA in the mouse tetrad after p.o. administration
Test | Δ9-THC | Potency Ratio (Compared with Antinociception) | AJA | Potency Ratio (Compared with Antinociception) |
|---|---|---|---|---|
| ED50 in mg / kg (95% CL) | ED50 in mg / kg (95% CL) | |||
| SA | 40 (22-74) | 0.4* (0.1-0.6) | 108 (66-175) | 1.8* (1.2-2.7) |
| MPE | 15 (10-23) | 1.0 | 37 (29-46) | 1.0 |
| RI | <10 | 1.6 (0.7-4.8, N.S.) | 30 (20-45) | 1.3 (0.9-1.9, N.S.) |
| RT | 33 (25-44) | (N.D.) | 59 (46-75) | (N.D.) |
N.S., not significant; N.D., not determined; SA, percent inhibition of spontaneous activity; RT, change in rectal temperature in degrees Celsius); RI, ring immobility. ED50s for each drug are expressed in milligrams per kilogram with 95% confidence intervals in parentheses. Potency ratios (and 95% confidence limits) for each drug were calculated with respect to the ED50 for producing antinociception.
↵* Potency for the measure is significantly different than potency for producing antinociception (p < 0.05).