TABLE 4
EC50 and Emax values for α-carbon-substituted and N-substituted β-phenylethylamine stimulation of cAMP formation in human TAAR1-expressing rGαsAV12-664 cells in the presence of 3 μM RX821002 and 10 μM alprenolol
Compound | Structure | EC50 | Emax | N |
|---|---|---|---|---|
| nM | % | |||
| d-Amphetamine |
| 994 ± 161 | 85.3 ± 2.2 | 3 |
| l-Amphetamine |
| 1720 ± 290 | 78.5 ± 0.9 | 3 |
| N-Methyl-β-phenylethylamine |
| 250 ± 45 | 93.4 ± 7.4 | 5 |
| N,N-Dimethyl-β-phenylethylamine |
| 1490 ± 120 | 97.1 ± 5.2 | 7 |