Effect of 5-HT (100 μM) and the mGlu2/3/8 receptor antagonist LY341495 on EPSC frequency (number/s) and amplitude (pA)
All of the values displayed are means ± S.E.
LY341495 | n | Basal | 5-HT | LY341495 | 5-HT/LY341495 |
|---|---|---|---|---|---|
| EPSC frequency | |||||
| 100 nM | 10 | 3.9 ± 0.7 | 32.1 ± 6.0 | 3.5 ± 0.9 | 35.8 ± 7.4 |
| 1 μM | 11 | 4.4 ± 1.0 | 32.8 ± 5.3 | 3.6 ± 0.9 | 45.8 ± 5.6a |
| 10 μM | 11 | 4.4 ± 0.9 | 20.0 ± 2.5 | 5.5 ± 1.7 | 33.9 ± 4.2a |
| 30 μM | 9 | 3.3 ± 0.8 | 22.5 ± 3.7 | 3.2 ± 0.9 | 35.3 ± 4.9a |
| EPSC amplitude | |||||
| 100 nM | 10 | 65.4 ± 3.0 | 81.8 ± 5.3 | 62.6 ± 5.2 | 83.9 ± 6.0 |
| 1 μM | 11 | 51.8 ± 3.3 | 74.2 ± 5.0 | 54.6 ± 3.9 | 83.7 ± 6.4a |
| 10 μM | 11 | 63.7 ± 4.9 | 78.5 ± 4.1 | 65.7 ± 4.7 | 98.6 ± 4.4a |
| 30 μM | 9 | 64.8 ± 3.1 | 80.3 ± 3.3 | 63.5 ± 4.8 | 96.2 ± 6.0a |
↵ a p < 0.001 compared with respective control (e.g., 5-HT versus 5-HT/LY341495).