Compared apparent dissociation constants of BF2.649 at the four classes of histamine receptors
Values obtained in human (h) H1, H3, and H4 receptors and guinea pig (gp) H2 receptors.
Receptor | Ligand | Ki |
|---|---|---|
| nM | ||
| hH1 R | [3H]Mepyramine | 1140 |
| gpH2 R | [125I]Iodoaminopotentidine | ∼5000 |
| hH3 R | [125I]Iodoproxyfan | 5.3 ± 2.2 |
| hH4 R | [3H]HA | >100,000 |