Intrinsic clearance values for 3 μM 4′,4″-diCl BZT in human and male Sprague-Dawley rat-pooled liver microsomes (0.8 mg/ml) and in human and rat recombinant P450s (50 pmol/ml)
The intrinsic clearance values in the recombinant P450s that share the same letter are not significantly different at α = 0.05.
Microsomal Preparation | Intrinsic Clearance* |
|---|---|
| Pooled human liver microsomes | 12.75 ± 2.65 |
| Pooled male rat liver microsomes | 21.46 ± 1.39 |
| Human CYP2C19 | 0.07 ± 0.01b |
| Human CYP2D6 | 0.04 ± 0.01b |
| Rat CYP2C11 | 1.46 ± 0.39a |
| Rat CYP3A1 | 0.08 ± 0.01b |
↵* Intrinsic clearance is reported as microliters per minute per milligram of protein for human liver microsomes and rat liver microsomes and as microliters per minute per picomole of P450 for the recombinant P450s (n = 3/reaction).