TABLE 2

Effects of sergliflozin-A, sergliflozin, the aglycon of sergliflozin, phlorizin, and phloretin on glucose transport by human GLUT1 in erythrocytes

Data are presented as means ± S.E.M. of percentage of inhibition from four samples.


Compound

100 nM

1 μM

10 μM

100 μM
Sergliflozin-A 0.7 ± 3.1 -3.2 ± 8.3 -12.7 ± 7.8 -20.3 ± 18.3
Sergliflozin 3.8 ± 10.5 -5.0 ± 12.2 -17.5 ± 8.4 22.9 ± 8.7
Aglycon of sergliflozin -13.6 ± 9.6 7.5 ± 1.6 -10.4 ± 11.5 31.5 ± 11.9
Phlorizin 19.8 ± 5.5 4.0 ± 15.0 1.9 ± 14.9 -1.4 ± 28.9
Phloretin
-21.7 ± 17.8
19.2 ± 6.0
72.2 ± 1.2**
101.2 ± 1.8**
  • ** p < 0.01 vs. control.