TABLE 1

Rapid effects of raloxifene on the relaxation of precontracted aortic rings from estrogen-replaced ovariectomized rats under inflammatory challenge

E2-replaced ovariectomized rats were treated with 0.1 or 1 mg/kg LPS for 4 h before sacrifice. Tension recording experiments in response to raloxifene were performed as described under Materials and Methods. Results indicate the percent relaxation of NA-precontracted tone and are expressed as mean of ± S.E.M. (n = 3 for each group).

Raloxifene LPS
0 0.1 1
log M mg/kg
-11 1.9 ± 1.5 3.0 ± 1.9 3.3 ± 0.8
-9 8.6 ± 1.5 10.1 ± 4.2 3.9 ± 2.4
-7 12.4 ± 1.0 13.4 ± 3.5 4.6 ± 2.0