TABLE 1

Functional pharmacological evaluation

pIC50 values represent means determined from at least three separate experiments.

Antagonist Rat P2X7 Human P2X7
[Ca2+]I (pIC50 ± S.E.M.)
    A-740003 7.75 ± 0.03 7.36 ± 0.04
    PPADS 5.10 ± 0.02 5.45 ± 0.03
    KN62 <4 4.88 ± 0.18
    BBG 5.08 ± 0.07 <4
Yo-Pro Activity (pIC50 ± S.E.M.)
    A-740003 7.00 ± 0.02 7.03 ± 0.04
    PPADS 5.92 ± 0.09 5.88 ± 0.03
    KN62 <4 6.67 ± 0.02
    BBG 6.22 ± 0.03 5.71 ± 0.09