TABLE 4

Percentage of inhibition of plasma and cortical Aβ₄₀, body weight change from baseline and plasma drug levels (mean ± S.E.M.) following 6 or 20 days of oral dosing with 1 mg/kg LY411,575 in CRND8 mice

Group	Aβ₄₀ Inhibition		Body Weight Change	Plasma Levels
Group	Plasma	Cortex	Body Weight Change	Plasma Levels
	%		g	ng/ml
Vehicle			+0.3 ± 0.7
Day 6	96^*	44^†	+0.3 ± 0.3	1.53 ± 0.31
Day 20	94^*	69^*	+0.3 ± 0.5	1.29 ± 0.22

↵* p < 0.005 and ^†p < 0.10 vs. vehicle, Dunnett's post hoc t test on raw data, not percentage of inhibition.