TABLE 3

Percentage of inhibition of plasma Aβ40, body weight change from baseline, thymus weight, and plasma drug levels (mean ± S.E.M.) following 6 days of oral dosing with 10 mg/kg LY411,575 in young and aged CRND8 mice

Group Plasma Aβ40 Inhibition Body Weight Change Thymus Weight Plasma Levels
% g mg ng/ml
Young (5-6 weeks)
    Vehicle +1.2 ± 0.4 47.36 ± 5.48
    10 100† -0.6 ± 0.1* 16.62 ± 1.47* 16.39 ± 5.18
Aged (16-25 months)
    Vehicle -1.7 ± 2.2 6.35 ± 1.66
    10 100† -3.8 ± 1.0 4.43 ± 0.82 27.18 ± 5.60

  • ↵* p < 0.003 vs. age-matched vehicle, t test.

  • ↵† p < 0.0001 vs. age-matched vehicle, t test on raw data, not percentage of inhibition.